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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
崔熠 《电信工程技术与标准化》2018,(11)
2017年4月12号第一颗国产高通量宽带卫星-中星16发射成功,Ka高通量宽带卫星网络在国内已经正式运行,本文就国内高通量卫星宽带业务做相应探讨。 相似文献
62.
Deepa Jonnalagadda Debin Wan Jerold Chun Bruce D. Hammock Yasuyuki Kihara 《International journal of molecular sciences》2021,22(9)
Polyunsaturated fatty acids (PUFAs) are essential FAs for human health. Cytochrome P450 oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids (EpFAs) and other oxylipins whose epoxide ring is opened by the soluble epoxide hydrolase (sEH/Ephx2), resulting in the formation of toxic and pro-inflammatory vicinal diols (dihydroxy-FAs). Pharmacological inhibition of sEH is a promising strategy for the treatment of pain, inflammation, cardiovascular diseases, and other conditions. We tested the efficacy of a potent, selective sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), in an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE). Prophylactic TPPU treatment significantly ameliorated EAE without affecting circulating white blood cell counts. TPPU accumulated in the spinal cords (SCs), which was correlated with plasma TPPU concentration. Targeted lipidomics in EAE SCs and plasma identified that TPPU blocked production of dihydroxy-FAs efficiently and increased some EpFA species including 12(13)-epoxy-octadecenoic acid (12(13)-EpOME) and 17(18)-epoxy-eicosatrienoic acid (17(18)-EpETE). TPPU did not alter levels of cyclooxygenase (COX-1/2) metabolites, while it increased 12-hydroxyeicosatetraenoic acid (12-HETE) and other 12/15-lipoxygenase metabolites. These analytical results are consistent with sEH inhibitors that reduce neuroinflammation and accelerate anti-inflammatory responses, providing the possibility that sEH inhibitors could be used as a disease modifying therapy, as well as for MS-associated pain relief. 相似文献
63.
Viktoria M. S. Kjær Loukas Ieremias Dr. Viktorija Daugvilaite Dr. Michael Lückmann Prof. Thomas M. Frimurer Prof. Trond Ulven Prof. Mette M. Rosenkilde Dr. Jon Våbenø 《ChemMedChem》2021,16(17):2623-2627
The G protein-coupled receptor GPR183/EBI2, which is activated by oxysterols, is a therapeutic target for inflammatory and metabolic diseases where both antagonists and agonists are of potential interest. Using the piperazine diamide core of the known GPR183 antagonist (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one (NIBR189) as starting point, we identified and sourced 79 structurally related compounds that were commercially available. In vitro screening of this compound collection using a Ca2+ mobilization assay resulted in the identification of 10 compounds with agonist properties. To enable establishment of initial structure-activity relationship trends, these were supplemented with five in-house compounds, two of which were also shown to be GPR183 agonists. Taken together, our findings suggest that the agonist activity of this compound series is dictated by the substitution pattern of one of the two distal phenyl rings, which functions as a molecular efficacy-switch. 相似文献
64.
Tetsuya Iida Dr. Yukihiro Itoh Yukari Takahashi Dr. Yasunobu Yamashita Dr. Takashi Kurohara Dr. Yuka Miyake Prof. Makoto Oba Prof. Takayoshi Suzuki 《ChemMedChem》2021,16(10):1609-1618
Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a therapeutic target for anti-prostate cancer agents, and recently we identified triazole 1 as an inhibitor of KDM5C. Compound 1 exhibited highly potent KDM5C-inhibitory activity in in vitro enzyme assays, but did not show strong anticancer effects. Therefore, a different approach is needed for the development of anticancer agents targeting KDM5C. Here, we attempted to identify KDM5C degraders by focusing on a protein-knockdown strategy. Compound 3 b , which was designed based on compound 1 , degraded KDM5C and inhibited the growth of prostate cancer PC-3 cells more strongly than compound 1 . These findings suggest that KDM5C degraders are more effective as anticancer agents than compounds that only inhibit the catalytic activity of KDM5C. 相似文献
65.
66.
Advances in the field of medical sciences and medical technology, and
present-day challenges, such as an aging population, rising medical expenses, and
lifestyle-related diseases, have collectively catalyzed a research ecosystem termed
“smart wellness.” This article describes the establishment of a smart wellness service platform designed to empower individuals to create a sense of balance in
their lives. Step-by-step details include service model, design, and architectural
considerations. As a proof of concept, implementation details of a Health
Improvement and Management Systems (HIMS) Hub, a Smart Wellness Service
Platform deployed in six cities in South Korea, are presented. An on-site survey
conducted in Busan Metropolitan City reveals the percentage of satisfied users to
be 91.3%. Furthermore, data gathered from 27,236 physical evaluations of users
from a Busan city center over the period of April 2013 to May 2018 reveal that
males and females in their 50s and 60s account for the highest number of participants, while males in their 70s have a higher rate of participation than females
in the same age group. 相似文献
67.
Salman Khan Mukhtaj Khan Nadeem Iqbal Mohd Amiruddin Abd Rahman Muhammad Khalis Abdul Karim 《计算机、材料和连续体(英文)》2022,72(2):2243-2258
Piwi-interacting Ribonucleic acids (piRNAs) molecule is a well-known subclass of small non-coding RNA molecules that are mainly responsible for maintaining genome integrity, regulating gene expression, and germline stem cell maintenance by suppressing transposon elements. The piRNAs molecule can be used for the diagnosis of multiple tumor types and drug development. Due to the vital roles of the piRNA in computational biology, the identification of piRNAs has become an important area of research in computational biology. This paper proposes a two-layer predictor to improve the prediction of piRNAs and their function using deep learning methods. The proposed model applies various feature extraction methods to consider both structure information and physicochemical properties of the biological sequences during the feature extraction process. The outcome of the proposed model is extensively evaluated using the k-fold cross-validation method. The evaluation result shows that the proposed predictor performed better than the existing models with accuracy improvement of 7.59% and 2.81% at layer I and layer II respectively. It is anticipated that the proposed model could be a beneficial tool for cancer diagnosis and precision medicine. 相似文献
68.
Target design methodologies (DfX) were developed to cope with specific engineering design issues such as cost-effectiveness, manufacturability, assemblability, maintainability, among others. However, DfX methodologies are undergoing the lack of real integration with 3D CAD systems. Their principles are currently applied downstream of the 3D modelling by following the well-known rules available from the literature and engineers’ know-how (tacit internal knowledge).This paper provides a method to formalize complex DfX engineering knowledge into explicit knowledge that can be reused for Advanced Engineering Informatics to aid designers and engineers in developing mechanical products. This research work wants to define a general method (ontology) able to couple DfX design guidelines (engineering knowledge) with geometrical product features of a product 3D model (engineering parametric data). A common layer for all DfX methods (horizontal) and dedicated layers for each DfX method (vertical) allow creating the suitable ontology for the systematic collection of the DfX rules considering each target. Moreover, the proposed framework is the first step for developing (future work) a software tool to assist engineers and designers during product development (3D CAD modelling).A design for assembly (DfA) case study shows how to collect assembly rules in the given framework. It demonstrates the applicability of the CAD-integrated DfX system in the mechanical design of a jig-crane. Several benefits are recognized: (i) systematic collection of DfA rules for informatics development, (ii) identification of assembly issues in the product development process, and (iii) reduction of effort and time during the design review. 相似文献
69.
一种基于语义关联的查询优化方法 总被引:7,自引:2,他引:5
提出了一种综合词法关系和语义分析的查询优化方法。通过对查询关键字词法特性和本体实例之间语义关联强弱的分析,提高了查询关键字到本体概念映射的完整性和准确率,帮助搜索引擎对用户的意图做出有效推测,解决了传统搜索引擎不能很好理解用户意图的问题。设计实现了相应的查询优化系统,实验表明该系统可以有效提高搜索的准确率。 相似文献
70.
阐述了以齿轮齿面寿命为目标的齿轮传动几何参数优化设计方法 ,该优化设计考虑了负荷大小、接触点几何形状、滑动速度、油膜厚度等因素的影响。以齿轮减速器为例说明了数学模型的建立方法 ,并通过实例进行了印证 ,结果表明该优化设计方法能为提高齿面寿命提供有价值的齿轮参数组合 相似文献